Organ Sparing Surgery for Breast Cancer Involving the Mamillo-Areolar Complex (MAC)

Date of publication

24 February 2026

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Assoc. Martin Karamanliev, PhD

Clinical case from practice

We present the case of a patient with invasive breast cancer located centrally and involving the mammillo-areolar complex (MAC). In the past, such a finding was considered an absolute indication for mastectomy (complete breast removal) because of the risk of incomplete resection and local recurrence.

After detailed imaging (mammography, ultrasonography and MRI), a multidisciplinary oncology board and discussion with the patient, the decision was made for organ-sparing surgery with an oncoplastic approach.

What does „organ-sparing surgery“ mean?

Organ-preserving surgery (lumpectomy / breast-conserving surgery) is:

  • Removal of the tumor with a sufficient surgical edge of healthy tissue
  • Retaining maximum volume from the breast
  • Preservation of the natural shape through oncoplastic techniques
  • Subsequent radiotherapy

In this case it was done:

  • Central resection with removal of the affected MAC
  • Breast reconstruction by oncoplastic technique
  • Biopsy of sentinel lymph nodes

Why is this important?

Until a few years ago, engaging the MAC almost automatically led to a mastectomy. Today, thanks to:

  • More accurate pre-operative diagnostics
  • Oncoplastic surgical techniques
  • Better understanding of tumour biology
  • Effective adjuvant therapy

it is possible in carefully selected patients to achieve cancer safety, combined with better cosmetic and psycho-emotional result.

Cancer Safety

Organ-sparing treatment is safe when:

  • The resection lines are „clean“ (no tumor at the surgical edges)
  • Patient receives postoperative radiotherapy
  • The case was discussed in a multidisciplinary team

Multiple international recommendations support this approach with proper patient selection.

What was the result?

  • Complete oncological resection
  • Satisfactory cosmetic result
  • Patient satisfaction

What do patients need to know?

  • Not every nipple engagement necessarily means removing the entire breast.
  • The possibilities of modern surgery have been greatly expanded.
  • Each case is individual and requires judgement by a specialist breast surgery team.